GHK-Cu, a peptide that combines glycine, histidine, and lysine with copper, has been studied in hair follicle models, for its reported effects on follicle counts, keratinocyte proliferation and scalp tissue.
How GHK-Cu acts in follicle models
GHK-Cu binds to stem cell receptors in hair follicles and may promote cell proliferation and fibroblast migration, both of which are involved in hair growth. In studies conducted in cell cultures and animal models, GHK-Cu has been shown to:
- Increase protein synthesis: This peptide stimulates the production of various proteins that are fundamental for the structure and function of hair.
- Stimulate angiogenesis: GHK-Cu may promote the formation of new blood vessels, thereby improving circulation in the scalp and the supply of nutrients to the follicles.
- Reduce inflammation: lower inflammatory signalling in the surrounding tissue.
What the follicle studies report
In one preclinical study, GHK-Cu was administered to mice with alopecia, resulting in a significant increase in the number of hair follicles compared to the control group. Researchers reported both increased hair growth and improved hair quality.
Another study conducted in dermal cell cultures showed that GHK-Cu increased the proliferation of keratinocytes, the cells responsible for hair and skin formation. These findings point to an effect on the hair cycle.