Synedica Laboratories

Intermediate

Metabolic peptides and adipose tissue research

An intermediate path through metabolic peptide research: retatrutide, AOD-9604 and SLU-PP-332, the lipolytic cascade in adipocytes, and the appetite circuits these compounds act on.
modules
3
articles
8
Reading time
29 min read

Path overview

  1. 01Mechanisms and comparisons2
  2. 02Peptides in metabolic research4
  3. 03Incretin receptor agonism2

What this path covers

  • Follow the HSL and ATGL cascade that releases fatty acids from adipocytes.
  • Compare retatrutide, AOD-9604 and SLU-PP-332 by receptor target.
  • Read depot differences between visceral and subcutaneous adipose tissue.
  • Locate GLP-1R, MC4R and GHS-R1a in the hypothalamic appetite circuits.
  • Review how these endpoints are measured in preclinical models.
  1. 01

    Module 01

    Mechanisms and comparisons

    1. 01AOD-9604 and full-length hGH compared3 min read
    2. 02The HSL and ATGL lipolysis cascade5 min read
  2. 02

    Module 02

    Peptides in metabolic research

    1. 01Visceral and subcutaneous fat compared4 min read
    2. 02MOTS-c, SS-31 and mitochondrial biogenesis3 min read
    3. 03Exercise-mimetic compounds in the laboratory3 min read
    4. 04NPY, AgRP and POMC appetite circuits3 min read
  3. 03

    Module 03

    Incretin receptor agonism

    1. 01Beta3-adrenergic signalling in adipocytes4 min read
    2. 02GLP-1 receptor pharmacology and agonist design4 min read
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