Synedica Laboratories

Intermediate

GH secretagogues and the IGF-1 axis

An intermediate path through growth hormone secretagogue research: ipamorelin, CJC-1295, sermorelin and tesamorelin, how each engages the GH axis, and what the preclinical readouts measure.
modules
3
articles
4
Reading time
16 min read

Path overview

  1. 01Introduction to GH secretagogues1
  2. 02Comparisons and combinations2
  3. 03IGF-1 axis readouts1

What this path covers

  • Understand the mechanisms of action of GH secretagogues.
  • Compare secretagogues by receptor target and pharmacokinetics.
  • Follow the GHRH and somatostatin balance that sets endogenous GH release.
  • Trace hepatic IGF-1 synthesis downstream of a GH pulse.
  • Review how body composition endpoints are measured in these models.
  1. 01

    Module 01

    Introduction to GH secretagogues

    1. 01What regulates endogenous GH release4 min read
  2. 02

    Module 02

    Comparisons and combinations

    1. 01Tesamorelin and sermorelin compared4 min read
    2. 02CJC-1295 and ipamorelin at the somatotroph4 min read
  3. 03

    Module 03

    IGF-1 axis readouts

    1. 01How GH secretagogues raise IGF-14 min read
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