Metabolic & Body Composition
AOD-9604
C-terminal fragment of human growth hormone (hGH 176-191). Studied for β3-adrenergic lipolysis in adipocytes without GH receptor binding.
Also known asAnti-Obesity Drug 9604 · hGH Fragment 177-191
Identity
Residue chain
One bead per amino acid residue, N-terminus to C-terminus. Long chains are shown truncated.
- Molecular weight
- 1815.1 Da
- Amino acid residues
- 15
- Half-life
- ~30 min
- CAS number
- 221231-10-3
Monograph
Specifications
- Research area
- Metabolic & Body Composition
- Half-life
- ~30 min
- Molecular weight
- 1815.1 Da
- Amino acid residues
- 15
- CAS number
- 221231-10-3
- Formula
- C₇₈H₁₄₉N₂₃O₂₆S₂
- Mechanism of action
- Synthetic C-terminal fragment of human growth hormone (hGH₁₇₆₋₁₉₁) that activates β₃-adrenergic receptor-mediated lipolysis in adipose tissue without binding the GH receptor or stimulating IGF-1 production. Enables selective study of fat metabolism pathways independent of GH's proliferative effects.
- Storage and handling
- Refrigerate at 2–8 °C after reconstitution. Powder is stable at room temperature for up to 24 months.
Research focus
- 01β₃-adrenergic receptor-mediated lipolysis in adipose tissue
- 02Selective fat metabolism without GH receptor binding
- 03IGF-1-independent weight regulation mechanisms
- 04Visceral and subcutaneous fat compartment studies
- 05Metabolic dysfunction and obesity models
Overview
AOD-9604 is the C-terminal fragment of human growth hormone (residues 176–191). It activates β₃-adrenergic lipolysis in adipocytes without binding the GH receptor, which lets a study separate lipolytic signalling from GH receptor activation and IGF-1 output. It appears in visceral and subcutaneous depot work and in metabolic model studies.