Metabolic & Body Composition
AOD-9604
Modified fragment of the C-terminal end of human growth hormone. Promotes lipolysis without the anabolic effects or impact on glucose of full GH.
Also known as: Anti-Obesity Drug 9604 · hGH Fragment 177-191
Specifications
| Research area | Metabolic & Body Composition | ||
|---|---|---|---|
| Half-life | ~30 min | ||
| Molecular weight | 1815.1 Da | ||
| Amino acid residues | 15 | ||
| CAS number | 221231-10-3 | ||
| Formula | C₇₈H₁₄₉N₂₃O₂₆S₂ | ||
Research areas
- Mechanism of action
- Synthetic C-terminal fragment of human growth hormone (hGH₁₇₆₋₁₉₁) that activates β₃-adrenergic receptor-mediated lipolysis in adipose tissue without binding the GH receptor or stimulating IGF-1 production. Enables selective study of fat metabolism pathways independent of GH's proliferative effects.
- Reported research ranges
- 300–600 mcg subcutaneously daily on an empty stomach.
- Reported adverse effects
- Generally well tolerated. Possible transient redness at the injection site. No impact on glucose.
- Storage and handling
- Refrigerate at 2–8 °C after reconstitution. Powder is stable at room temperature for up to 24 months.
Research focus
- β₃-adrenergic receptor-mediated lipolysis in adipose tissue
- Selective fat metabolism without GH receptor binding
- IGF-1-independent weight regulation mechanisms
- Visceral and subcutaneous fat compartment studies
- Metabolic dysfunction and obesity models
Overview
AOD-9604 is a fragment of the C-terminal end of human growth hormone, which has been the subject of various studies related to lipolysis, fat metabolism, and body weight regulation. Unlike the complete growth hormone, AOD-9604 does not exhibit proliferative effects, making it an area of interest in preclinical models to better understand the mechanisms of fat loss.
Researchers are focused on evaluating how AOD-9604 may influence body fat reduction and metabolic enhancement. This research is essential for developing strategies that may help combat obesity and improve metabolic health, making AOD-9604 a key peptide in the field of metabolic research.
This material is published for scientific and educational reference. It is not medical advice, not a treatment recommendation, and not an offer to sell. Compounds discussed are for research and laboratory use only.
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