Recovery & Tissue Repair
BPC-157
Synthetic pentadecapeptide related to a gastric protein. Studied in tissue repair models for VEGF-linked angiogenesis and fibroblast migration.
Also known asBody Protection Compound 157
Identity
Residue chain
One bead per amino acid residue, N-terminus to C-terminus. Long chains are shown truncated.
- Molecular weight
- 1419.5 Da
- Amino acid residues
- 15
- Half-life
- 4–6 h
- CAS number
- 137525-51-0
Monograph
Specifications
- Research area
- Recovery & Tissue Repair
- Half-life
- 4–6 h
- Molecular weight
- 1419.5 Da
- Amino acid residues
- 15
- CAS number
- 137525-51-0
- Formula
- C₆₂H₁₀₀N₁₅O₂₂
- Sequence
- Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val
- Designation
- Body Protection Compound 157 (BPC-157)
Pharmacokinetics
- Half-life
- 4–6 h (intramuscular)
- T-max
- ~30 min
- Bioavailability
- Low oral; high subcutaneous
- Route
- Subcutaneous / intramuscular (research use)
Receptor targets
- VEGFR2Angiogenesis upregulation
- Growth hormone receptorIndirect modulation of healing
- eNOS pathwayNitric oxide signaling
Signalling cascade
- 1Tissue injury
- 2VEGF / NO release
- 3Fibroblast migration
- 4Angiogenesis
- 5Tendon / GI repair
- Mechanism of action
- Synthetic pentadecapeptide that activates the nitric oxide system and promotes angiogenesis via VEGF upregulation. Modulates PDGF receptor signaling and accelerates fibroblast migration in tendon, ligament, and gastrointestinal tissue repair models.
- Storage and handling
- Refrigerate at 2–8 °C once reconstituted. The lyophilized powder can be stored at room temperature for up to 24 months.
Research focus
- 01Gastrointestinal mucosal protection and ulcer healing
- 02Tendon and ligament repair via fibroblast activation
- 03Angiogenesis and microvascular growth through VEGF modulation
- 04Inflammatory resolution and cytokine regulation
- 05Bone and joint repair in preclinical rodent models
Overview
BPC-157 is a synthetic pentadecapeptide related to a protein found in gastric juice. Preclinical work covers VEGF-linked angiogenesis, nitric oxide signalling, fibroblast migration in tendon and ligament models, and gastrointestinal mucosal models.