Recovery & Tissue Repair
BPC-157
15-amino acid peptide derived from gastric BPC binding protein. It accelerates the healing of tissues, tendons, and muscles.
Also known as: Body Protection Compound 157
Specifications
| Research area | Recovery & Tissue Repair | ||
|---|---|---|---|
| Half-life | 4–6 h | ||
| Molecular weight | 1419.5 Da | ||
| Amino acid residues | 15 | ||
| CAS number | 137525-51-0 | ||
| Formula | C₆₂H₁₀₀N₁₅O₂₂ | ||
| Sequence | Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val | ||
| Designation | Body Protection Compound 157 (BPC-157) | ||
Pharmacokinetics
| Half-life | 4–6 h (intramuscular) | ||
|---|---|---|---|
| T-max | ~30 min | ||
| Bioavailability | Low oral; high subcutaneous | ||
| Route | Subcutaneous / intramuscular (research use) | ||
Receptor targets
| VEGFR2 | Angiogenesis upregulation | ||
|---|---|---|---|
| Growth hormone receptor | Indirect modulation of healing | ||
| eNOS pathway | Nitric oxide signaling | ||
Signalling cascade
- Tissue injury
- VEGF / NO release
- Fibroblast migration
- Angiogenesis
- Tendon / GI repair
Research areas
- Mechanism of action
- Synthetic pentadecapeptide that activates the nitric oxide system and promotes angiogenesis via VEGF upregulation. Modulates PDGF receptor signaling and accelerates fibroblast migration in tendon, ligament, and gastrointestinal tissue repair models.
- Reported research ranges
- 200–500 mcg/day subcutaneously or intramuscularly, administered near the injured area.
- Reported adverse effects
- Generally well tolerated. May cause mild nausea, transient dizziness, or redness at the injection site.
- Storage and handling
- Refrigerate at 2–8 °C once reconstituted. The lyophilized powder can be stored at room temperature for up to 24 months.
Research focus
- Gastrointestinal mucosal protection and ulcer healing
- Tendon and ligament repair via fibroblast activation
- Angiogenesis and microvascular growth through VEGF modulation
- Inflammatory resolution and cytokine regulation
- Bone and joint repair in preclinical rodent models
Overview
BPC-157 is a synthetic peptide composed of 15 amino acids that has been the subject of research in preclinical models. This peptide is primarily studied for its ability to promote tissue repair, a crucial process in the recovery from injuries and in the overall health of tissues.
Additionally, BPC-157 is investigated for its role in angiogenesis, which is the formation of new blood vessels, and its potential to provide gastrointestinal protection. Scientists focus on these areas due to their implications for the research into various conditions and to better understand the healing mechanisms in the body.
Synedica formulation
Synedica publishes a formulation record and batch certificates for this compound.
This material is published for scientific and educational reference. It is not medical advice, not a treatment recommendation, and not an offer to sell. Compounds discussed are for research and laboratory use only.
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