Growth Hormone Axis
CJC-1295
GHRH analogue carrying an albumin-binding complex that extends its plasma half-life. Studied for sustained GHRH receptor stimulation and IGF-1 output.
Also known asCJC-1295 DAC · Drug Affinity Complex
Identity
Residue chain
One bead per amino acid residue, N-terminus to C-terminus. Long chains are shown truncated.
- Molecular weight
- 3647.1 Da
- Amino acid residues
- 30
- Half-life
- 8–9 days
- CAS number
- 863288-34-0
Monograph
Specifications
- Research area
- Growth Hormone Axis
- Half-life
- 8–9 days
- Molecular weight
- 3647.1 Da
- Amino acid residues
- 30
- CAS number
- 863288-34-0
- Formula
- C₁₆₅H₂₆₉N₄₇O₄₆
- Mechanism of action
- GHRH analogue modified with a Drug Affinity Complex (DAC) that covalently binds serum albumin via a reactive ester linkage, conferring an extended plasma half-life of approximately 8 days. Provides sustained pituitary GHRH receptor stimulation for amplified GH pulse magnitude and elevated IGF-1 over multi-day periods.
- Storage and handling
- Refrigerate at 2–8 °C after reconstitution. Powder is stable for up to 24 months at room temperature.
Research focus
- 01Albumin-binding pharmacokinetics and extended half-life mechanisms
- 02Sustained GH pulse amplification over multi-day cycles
- 03IGF-1 elevation and anabolic signaling
- 04Body composition and lean mass research
- 05Comparison of episodic vs. sustained GHRH receptor stimulation
Overview
CJC-1295 with DAC is a GHRH analogue carrying an albumin-binding domain, which extends its plasma half-life to approximately 8 days. That half-life makes it a tool for comparing sustained GHRH receptor stimulation with episodic stimulation, and for following GH pulse amplitude and the IGF-1 axis in rodent models.