Growth Hormone Axis
CJC-1295
A long-acting GHRH analog that elevates baseline levels of GH and IGF-1 for several days. Frequently combined with Ipamorelin for synergistic effects.
Also known as: CJC-1295 DAC · Drug Affinity Complex
Specifications
| Research area | Growth Hormone Axis | ||
|---|---|---|---|
| Half-life | 8–9 days | ||
| Molecular weight | 3647.1 Da | ||
| Amino acid residues | 30 | ||
| CAS number | 863288-34-0 | ||
| Formula | C₁₆₅H₂₆₉N₄₇O₄₆ | ||
Research areas
- Mechanism of action
- GHRH analogue modified with a Drug Affinity Complex (DAC) that covalently binds serum albumin via a reactive ester linkage, conferring an extended plasma half-life of approximately 8 days. Provides sustained pituitary GHRH receptor stimulation for amplified GH pulse magnitude and elevated IGF-1 over multi-day periods.
- Reported research ranges
- 1–2 mg subcutaneously once a week (with DAC). Without DAC: 100 mcg daily.
- Reported adverse effects
- Water retention, numbness in hands, increased appetite. Possible fatigue on the day of injection.
- Storage and handling
- Refrigerate at 2–8 °C after reconstitution. Powder is stable for up to 24 months at room temperature.
Research focus
- Albumin-binding pharmacokinetics and extended half-life mechanisms
- Sustained GH pulse amplification over multi-day cycles
- IGF-1 elevation and anabolic signaling
- Body composition and lean mass research
- Comparison of episodic vs. sustained GHRH receptor stimulation
Overview
CJC-1295 DAC is an analogue of growth hormone-releasing hormone (GHRH) that features an albumin-binding domain, which provides it with a prolonged half-life compared to other peptides. This characteristic allows CJC-1295 DAC to be utilized in research focusing on sustained growth hormone release, which may have significant implications in the study of anabolism and body composition.
Scientists are interested in CJC-1295 DAC due to its potential to enhance the understanding of the mechanisms regulating growth hormone secretion in preclinical models. Research in this area could contribute to developments in fields such as exercise physiology, metabolism, and metabolic health.
This material is published for scientific and educational reference. It is not medical advice, not a treatment recommendation, and not an offer to sell. Compounds discussed are for research and laboratory use only.
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