Longevity & Cellular Health
GDF-11
TGF-β superfamily growth factor studied through ActRII, ALK4/5 and SMAD2/3 signalling in stem cell and cardiac ageing models.
Also known asGrowth Differentiation Factor 11 · BMP-11
Identity
Residue chain
One bead per amino acid residue, N-terminus to C-terminus. Long chains are shown truncated.
- Molecular weight
- 25000 Da
- Amino acid residues
- 407
- Half-life
- ~30–60 minutes
- CAS number
- —
Monograph
Specifications
- Research area
- Longevity & Cellular Health
- Half-life
- ~30–60 minutes
- Molecular weight
- 25000 Da
- Amino acid residues
- 407
- Mechanism of action
- Member of the TGF-β superfamily that activates ActRII/ALK4/5 receptors and the SMAD2/3 pathways. It regulates stem cell differentiation, cardiac function, and neurogenesis. Its levels decrease with age.
- Storage and handling
- Refrigerate at 2–8 °C after reconstitution. Highly sensitive.