Longevity & Cellular Health
GDF-11
Growth differentiation factor with systemic rejuvenation effects. Involved in the reversal of cardiac and cerebral aging in parabiosis studies.
Also known as: Growth Differentiation Factor 11 · BMP-11
Specifications
| Research area | Longevity & Cellular Health | ||
|---|---|---|---|
| Half-life | ~30–60 minutes | ||
| Molecular weight | 25000 Da | ||
| Amino acid residues | 407 | ||
Research areas
LongevityRejuvenationCardiacCognition
- Mechanism of action
- Member of the TGF-β superfamily that activates ActRII/ALK4/5 receptors and the SMAD2/3 pathways. It regulates stem cell differentiation, cardiac function, and neurogenesis. Its levels decrease with age.
- Reported research ranges
- 0.1–0.3 mg/kg subcutaneously. Protocol under active research.
- Reported adverse effects
- Limited safety data in humans. Experimental use.
- Storage and handling
- Refrigerate at 2–8 °C after reconstitution. Highly sensitive.
This material is published for scientific and educational reference. It is not medical advice, not a treatment recommendation, and not an offer to sell. Compounds discussed are for research and laboratory use only.
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