Metabolic & Body Composition
GLP-1 (7-37)
Endogenous incretin with a very short native half-life. The molecular reference point for semaglutide and the other GLP-1R agonists.
Also known asGlucagon-like Peptide-1 · GLP-1 receptor agonist
Identity
Residue chain
One bead per amino acid residue, N-terminus to C-terminus. Long chains are shown truncated.
- Molecular weight
- 3298.7 Da
- Amino acid residues
- 31
- Half-life
- ~2 minutes (native)
- CAS number
- —
Monograph
Specifications
- Research area
- Metabolic & Body Composition
- Half-life
- ~2 minutes (native)
- Molecular weight
- 3298.7 Da
- Amino acid residues
- 31
- Mechanism of action
- It binds to the GLP-1R receptor on pancreatic beta cells, stimulating glucose-dependent insulin secretion. It inhibits gastric emptying, reduces glucagon secretion, and acts on the hypothalamus to decrease appetite.
- Storage and handling
- Store at 2–8 °C.