Endocrine & Reproductive
Gonadorelin
Synthetic gonadotropin-releasing hormone studied for pulsatile GnRH receptor signalling and downstream LH and FSH release.
Also known asGnRH · LHRH · Luteinizing Hormone Releasing Hormone
Identity
Residue chain
One bead per amino acid residue, N-terminus to C-terminus. Long chains are shown truncated.
- Molecular weight
- 1182.3 Da
- Amino acid residues
- 10
- Half-life
- ~2–10 minutes
- CAS number
- —
Monograph
Specifications
- Research area
- Endocrine & Reproductive
- Half-life
- ~2–10 minutes
- Molecular weight
- 1182.3 Da
- Amino acid residues
- 10
- Mechanism of action
- It binds to GnRH receptors in gonadotropic cells of the anterior pituitary, stimulating the pulsatile synthesis and release of LH and FSH. Pulsatile administration maintains gonadal function, while continuous administration suppresses it.
- Storage and handling
- Refrigerate at 2–8 °C after reconstitution.