Longevity & Cellular Health
Humanin
21-residue mitochondrial-derived peptide studied through gp130 and STAT3 signalling, BAX inhibition and beta-amyloid toxicity models.
Also known asHN · Mitochondria-derived peptide
Identity
Residue chain
One bead per amino acid residue, N-terminus to C-terminus. Long chains are shown truncated.
- Molecular weight
- 2887.3 Da
- Amino acid residues
- 21
- Half-life
- ~30–60 minutes
- CAS number
- —
Monograph
Specifications
- Research area
- Longevity & Cellular Health
- Half-life
- ~30–60 minutes
- Molecular weight
- 2887.3 Da
- Amino acid residues
- 21
- Mechanism of action
- It binds to gp130/CNTFR/IL-6ST receptors, activating the JAK/STAT3 pathway, thereby promoting cell survival. It inhibits the pro-apoptotic protein BAX and blocks beta-amyloid toxicity. It also modulates insulin signalling in the reported models.
- Storage and handling
- Refrigerate at 2–8 °C after reconstitution.