Longevity & Cellular Health
Humanin
Mitochondrial peptide of 21 amino acids with potent neuroprotective and effects in cellular longevity models. It protects against beta-amyloid-induced apoptosis and enhances insulin sensitivity.
Also known as: HN · Mitochondria-derived peptide
Specifications
| Research area | Longevity & Cellular Health | ||
|---|---|---|---|
| Half-life | ~30–60 minutes | ||
| Molecular weight | 2887.3 Da | ||
| Amino acid residues | 21 | ||
Research areas
NeuroprotectionCellular longevityLongevityInsulin
- Mechanism of action
- It binds to gp130/CNTFR/IL-6ST receptors, activating the JAK/STAT3 pathway, thereby promoting cell survival. It inhibits the pro-apoptotic protein BAX and blocks beta-amyloid toxicity. It has anti-diabetic effects by enhancing insulin signaling.
- Reported research ranges
- 50–500 mcg subcutaneously daily or on alternate days.
- Reported adverse effects
- Limited safety data in humans. Well tolerated in preliminary studies.
- Storage and handling
- Refrigerate at 2–8 °C after reconstitution.
This material is published for scientific and educational reference. It is not medical advice, not a treatment recommendation, and not an offer to sell. Compounds discussed are for research and laboratory use only.
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