Anabolic & Growth Factors
IGF-1 LR3
IGF-1 variant with 13 extra N-terminal residues and low IGFBP affinity. Studied through IGF-1R, PI3K/AKT and MAPK signalling.
Also known asLong R3 IGF-1 · Insulin-like Growth Factor-1 LR3
Identity
Residue chain
One bead per amino acid residue, N-terminus to C-terminus. Long chains are shown truncated.
- Molecular weight
- 9200 Da
- Amino acid residues
- 83
- Half-life
- ~20–30 hours
- CAS number
- —
Monograph
Specifications
- Research area
- Anabolic & Growth Factors
- Half-life
- ~20–30 hours
- Molecular weight
- 9200 Da
- Amino acid residues
- 83
- Mechanism of action
- It binds to IGF-1R receptors with higher affinity and lower binding to IGFBP proteins, resulting in increased bioavailability. It activates the PI3K/AKT and MAPK pathways, promoting muscle hypertrophy, protein synthesis, and satellite cell differentiation.
- Storage and handling
- Refrigerate at 2–8 °C after reconstitution. Do not freeze. Stable for 30 days.