Endocrine & Reproductive
Kisspeptin-10
Decapeptide studied at KISS1R (GPR54) on GnRH neurons, upstream of pulsatile GnRH release and gonadotropin secretion.
Also known asKP-10 · Metastin fragment
Identity
Residue chain
One bead per amino acid residue, N-terminus to C-terminus. Long chains are shown truncated.
- Molecular weight
- 1302.5 Da
- Amino acid residues
- 10
- Half-life
- ~10–27 minutes
- CAS number
- —
Monograph
Specifications
- Research area
- Endocrine & Reproductive
- Half-life
- ~10–27 minutes
- Molecular weight
- 1302.5 Da
- Amino acid residues
- 10
- Mechanism of action
- It binds to the KISS1R (GPR54) receptor on GnRH neurons in the hypothalamus, stimulating the pulsatile release of GnRH and the subsequent secretion of LH and FSH by the pituitary gland. It increases gonadal production of testosterone and estradiol.
- Storage and handling
- Refrigerate at 2–8 °C after reconstitution.