Immune & Anti-inflammatory
KPV
C-terminal tripeptide of α-MSH studied for NF-κB inhibition and cytokine release in intestinal mucosal and immune models.
Also known asLys-Pro-Val · MSH C-terminal tripeptide
Identity
Residue chain
One bead per amino acid residue, N-terminus to C-terminus. Long chains are shown truncated.
- Molecular weight
- 342.4 Da
- Amino acid residues
- 3
- Half-life
- 2–4 h (est.)
- CAS number
- 42279-29-8
Monograph
Specifications
- Research area
- Immune & Anti-inflammatory
- Half-life
- 2–4 h (est.)
- Molecular weight
- 342.4 Da
- Amino acid residues
- 3
- CAS number
- 42279-29-8
- Formula
- C₁₆H₂₉N₅O₅
- Mechanism of action
- C-terminal tripeptide of α-MSH that inhibits NF-κB nuclear translocation and downstream pro-inflammatory cytokine release (IL-6, TNF-α, IL-1β) through MC1R-independent pathways. Investigated for intestinal mucosal protection and immune regulation without the melanotropic effects of the full α-MSH sequence.
- Storage and handling
- Refrigerate at 2–8 °C after reconstitution. Stable at room temperature in powder form.
Research focus
- 01NF-κB inhibition and pro-inflammatory cytokine suppression
- 02Intestinal mucosal healing and barrier protection
- 03Immune modulation via MC1R-independent signaling
- 04Inflammatory bowel disease models (colitis, Crohn's)
- 05Mast cell and macrophage activation regulation
Overview
KPV is the C-terminal tripeptide of α-MSH. It inhibits NF-κB nuclear translocation and the downstream release of IL-6, TNF-α and IL-1β through MC1R-independent pathways. Preclinical work uses it in intestinal mucosal and colitis models and in mast cell and macrophage activation assays.