Immune & Anti-inflammatory
KPV
Tripeptide derived from the C-terminal end of α-MSH. A potent intestinal anti-inflammatory agent with promising effects in IBD (inflammatory bowel disease).
Also known as: Lys-Pro-Val · MSH C-terminal tripeptide
Specifications
| Research area | Immune & Anti-inflammatory | ||
|---|---|---|---|
| Half-life | 2–4 h (est.) | ||
| Molecular weight | 342.4 Da | ||
| Amino acid residues | 3 | ||
| CAS number | 42279-29-8 | ||
| Formula | C₁₆H₂₉N₅O₅ | ||
Research areas
- Mechanism of action
- C-terminal tripeptide of α-MSH that inhibits NF-κB nuclear translocation and downstream pro-inflammatory cytokine release (IL-6, TNF-α, IL-1β) through MC1R-independent pathways. Investigated for intestinal mucosal protection and immune regulation without the melanotropic effects of the full α-MSH sequence.
- Reported research ranges
- 500 mcg–1 mg orally or subcutaneously daily.
- Reported adverse effects
- Excellent tolerability. Minimal side effects reported.
- Storage and handling
- Refrigerate at 2–8 °C after reconstitution. Stable at room temperature in powder form.
Research focus
- NF-κB inhibition and pro-inflammatory cytokine suppression
- Intestinal mucosal healing and barrier protection
- Immune modulation via MC1R-independent signaling
- Inflammatory bowel disease models (colitis, Crohn's)
- Mast cell and macrophage activation regulation
Overview
KPV is an anti-inflammatory tripeptide derived from alpha-MSH, which has garnered attention from researchers due to its unique properties in modulating inflammatory pathways. This peptide is being studied for its potential to support intestinal healing, making it a promising approach in the field of biomedical research.
Scientists are exploring how KPV may regulate immune responses in preclinical models, which could provide valuable insights into its use in the research into various inflammatory conditions. As research progresses, the mechanisms of action of this peptide are being unveiled, which could open new avenues for its application in the future.
This material is published for scientific and educational reference. It is not medical advice, not a treatment recommendation, and not an offer to sell. Compounds discussed are for research and laboratory use only.
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