Immune & Anti-inflammatory
LL-37
Human cathelicidin-derived antimicrobial peptide studied for membrane disruption and for FPRL1, TLR4 and P2X7 signalling.
Also known asCathelicidin · hCAP18
Identity
Residue chain
One bead per amino acid residue, N-terminus to C-terminus. Long chains are shown truncated.
- Molecular weight
- 4494.1 Da
- Amino acid residues
- 37
- Half-life
- ~30 minutes
- CAS number
- —
Monograph
Specifications
- Research area
- Immune & Anti-inflammatory
- Half-life
- ~30 minutes
- Molecular weight
- 4494.1 Da
- Amino acid residues
- 37
- Mechanism of action
- Disrupts bacterial membranes through electrostatic interactions and forms lipid pores. Additionally, it activates FPRL1, TLR4, and P2X7 receptors, modulating pro-inflammatory cytokines and stimulating neutrophil chemotaxis.
- Storage and handling
- Refrigerate at 2–8 °C after reconstitution.