Endocrine & Reproductive
Melanotan 2
Synthetic analog of the melanocyte-stimulating hormone (α-MSH). Promotes skin tanning, reduces appetite, and enhances sexual function.
Also known as: MT-2 · Melanotan II
Specifications
| Research area | Endocrine & Reproductive | ||
|---|---|---|---|
| Half-life | 2–3 h | ||
| Molecular weight | 1024.2 Da | ||
| Amino acid residues | 7 | ||
| CAS number | 121062-08-6 | ||
| Formula | C₅₀H₆₉N₁₅O₉ | ||
Research areas
- Mechanism of action
- Synthetic cyclic heptapeptide analogue of α-MSH with non-selective agonist activity at MC1R, MC3R, MC4R, and MC5R. Activates eumelanin synthesis in skin melanocytes via MC1R/cAMP/PKA cascade, and modulates appetite and energy balance centrally through MC3R and MC4R.
- Reported research ranges
- 0.5–1 mg subcutaneously, starting with low doses to assess tolerance. Use with sun protection.
- Reported adverse effects
- Nausea, facial flushing, spontaneous erections, darkening of moles, hyperpigmentation.
- Storage and handling
- Refrigerate at 2–8 °C after reconstitution. Protect from light.
Research focus
- Melanocortin receptor pharmacology (MC1R–MC5R selectivity)
- Skin pigmentation via MC1R/cAMP/PKA-mediated eumelanin synthesis
- Appetite suppression and energy balance through MC4R
- Melanocyte biology and photoprotection models
- Central melanocortin system modulation
Overview
Melanotan II is a synthetic analog of alpha-melanocyte-stimulating hormone, a natural hormone that influences skin pigmentation. This peptide has garnered attention in the research field due to its ability to activate melanocortin receptors, which has significant implications for skin pigmentation, libido, and appetite suppression. Studies in preclinical models have explored how Melanotan II may induce a faster and more lasting tan, as well as its potential to influence feeding behavior.
Scientists are investigating Melanotan II not only for its interest in skin pigmentation but also for its effects on the endocrine system and its ability to modulate the body's response to various stimuli. This makes it a relevant area of study for better understanding the interaction between hormones, behavior, and physiology.
Synedica formulation
Synedica publishes a formulation record and batch certificates for this compound.
This material is published for scientific and educational reference. It is not medical advice, not a treatment recommendation, and not an offer to sell. Compounds discussed are for research and laboratory use only.
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