Longevity & Cellular Health
MOTS-c
Mitochondrial-derived peptide studied for AMPK activation, the DHFR-purine pathway and glucose metabolism in rodent models.
Also known asMitochondrial Open Reading Frame of the 12S rRNA-c
Identity
Residue chain
One bead per amino acid residue, N-terminus to C-terminus. Long chains are shown truncated.
- Molecular weight
- 2174.5 Da
- Amino acid residues
- 16
- Half-life
- ~30–60 minutes
- CAS number
- —
Monograph
Specifications
- Research area
- Longevity & Cellular Health
- Half-life
- ~30–60 minutes
- Molecular weight
- 2174.5 Da
- Amino acid residues
- 16
- Mechanism of action
- Activates AMPK (cellular energy sensor) and inhibits the DHFR-purine pathway, reprogramming glucose metabolism towards the pentose phosphate pathway. Translocates to the nucleus under stress to regulate gene expression and the antioxidant response.
- Storage and handling
- Refrigerate at 2–8 °C after reconstitution.