Cognitive & Neurological
PE22-28
Spadin-derived peptide studied for TREK-1 channel block and raised serotonergic neuron excitability in preclinical mood models.
Also known asSpadin analogue
Identity
Residue chain
One bead per amino acid residue, N-terminus to C-terminus. Long chains are shown truncated.
- Molecular weight
- 830.0 Da
- Amino acid residues
- 7
- Half-life
- ~1–2 hours
- CAS number
- —
Monograph
Specifications
- Research area
- Cognitive & Neurological
- Half-life
- ~1–2 hours
- Molecular weight
- 830.0 Da
- Amino acid residues
- 7
- Mechanism of action
- Blocks the TREK-1 potassium channel, which increases the excitability of serotonergic neurons in the raphe. The effect is similar to SSRIs but with a much faster onset of action.
- Storage and handling
- Refrigerate at 2–8 °C.