Cognitive & Neurological
Selank
Synthetic heptapeptide analogue of tuftsin studied for GABA-A modulation, BDNF expression and enkephalinase inhibition.
Also known asTP-7
Identity
Residue chain
One bead per amino acid residue, N-terminus to C-terminus. Long chains are shown truncated.
- Molecular weight
- 863.0 Da
- Amino acid residues
- 7
- Half-life
- ~10–15 min
- CAS number
- 129954-34-3
Monograph
Specifications
- Research area
- Cognitive & Neurological
- Half-life
- ~10–15 min
- Molecular weight
- 863.0 Da
- Amino acid residues
- 7
- CAS number
- 129954-34-3
- Formula
- C₃₃H₅₇N₁₁O₉
- Mechanism of action
- Synthetic heptapeptide analogue of tuftsin (Thr-Lys-Pro-Arg-Pro-Gly-Pro) that modulates GABA-A receptor function, elevates BDNF expression in hippocampal neurons, and inhibits enkephalin-degrading enzymes (enkephalinase) to prolong endogenous opioid activity.
- Storage and handling
- Refrigerate at 2–8 °C. Sensitive to light and heat.
Research focus
- 01GABA-A receptor modulation and anxiolytic signaling
- 02BDNF upregulation in hippocampal neuron models
- 03Enkephalinase inhibition and endogenous opioid stability
- 04Cognitive function and learning/memory models
- 05Neuroprotection under stress and hypoxic conditions
Overview
Selank is a synthetic heptapeptide analogue of tuftsin, stabilised with a Pro-Gly-Pro extension. Rodent work covers GABA-A receptor modulation, BDNF expression in hippocampal neurons through TrkB, and inhibition of enkephalin-degrading enzymes, with anxiety and learning paradigms as the behavioural read-outs.