Cognitive & Neurological
Selank
Synthetic anxiolytic peptide derived from tuftsin. It reduces anxiety and enhances cognitive function without the sedative or addictive effects associated with benzodiazepines.
Also known as: TP-7
Specifications
| Research area | Cognitive & Neurological | ||
|---|---|---|---|
| Half-life | ~10–15 min | ||
| Molecular weight | 863.0 Da | ||
| Amino acid residues | 7 | ||
| CAS number | 129954-34-3 | ||
| Formula | C₃₃H₅₇N₁₁O₉ | ||
Research areas
- Mechanism of action
- Synthetic heptapeptide analogue of tuftsin (Thr-Lys-Pro-Arg-Pro-Gly-Pro) that modulates GABA-A receptor function, elevates BDNF expression in hippocampal neurons, and inhibits enkephalin-degrading enzymes (enkephalinase) to prolong endogenous opioid activity.
- Reported research ranges
- 250–3000 mcg intranasally or subcutaneously, 1–3 times per day.
- Reported adverse effects
- Mild initial sedation, slight bitter taste when administered intranasally. Non-addictive and non-sedating with continuous use.
- Storage and handling
- Refrigerate at 2–8 °C. Sensitive to light and heat.
Research focus
- GABA-A receptor modulation and anxiolytic signaling
- BDNF upregulation in hippocampal neuron models
- Enkephalinase inhibition and endogenous opioid stability
- Cognitive function and learning/memory models
- Neuroprotection under stress and hypoxic conditions
Overview
Selank is a stabilized heptapeptide analog designed for preclinical research in various areas, including anxiety modulation and cognitive enhancement. This peptide has garnered the interest of scientists due to its neuroprotective properties and its potential to influence neuronal signaling. Selank is presented as a valuable tool for the study of complex biological mechanisms.
In preclinical models, Selank has shown promise in regulating stress and anxiety-related responses, as well as in enhancing cognitive functions. These characteristics make it a focal point of interest for researchers seeking to better understand how peptides can influence mental health and cognitive abilities.
This material is published for scientific and educational reference. It is not medical advice, not a treatment recommendation, and not an offer to sell. Compounds discussed are for research and laboratory use only.
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