Growth Hormone Axis
Sermorelin
Synthetic GHRH(1-29) analogue that binds the pituitary GHRH receptor. Studied as a model of pulsatile GH release with intact feedback.
Also known asGRF 1-29 NH2 · GHRH(1-29)
Identity
Residue chain
One bead per amino acid residue, N-terminus to C-terminus. Long chains are shown truncated.
- Molecular weight
- 3357.9 Da
- Amino acid residues
- 29
- Half-life
- ~12 min
- CAS number
- 86168-78-7
Monograph
Specifications
- Research area
- Growth Hormone Axis
- Half-life
- ~12 min
- Molecular weight
- 3357.9 Da
- Amino acid residues
- 29
- CAS number
- 86168-78-7
- Formula
- C₁₄₉H₂₄₆N₄₄O₄₂S
- Mechanism of action
- Synthetic 29-amino acid analogue of endogenous GHRH(1-44) that binds the pituitary GHRH receptor to stimulate pulsatile GH release. Preserves natural pituitary feedback through intact somatostatin regulation, making it a physiologically representative model for GH axis research.
- Storage and handling
- Refrigerate at 2–8 °C after reconstitution. The powder is stable at room temperature for up to 18 months.
Research focus
- 01Pulsatile GH release and GHRH receptor binding kinetics
- 02Lean tissue signaling and nitrogen retention models
- 03Pituitary somatotroph cell stimulation
- 04Somatostatin feedback regulation of the GH axis
- 05Age-related GH decline and secretagogue response
Overview
Sermorelin is a synthetic 29-residue analogue of endogenous GHRH. It binds the pituitary GHRH receptor to produce short, narrow GH pulses with somatostatin feedback left intact, which suits models of GH axis regulation and of the age-related decline in secretagogue response.