Growth Hormone Axis
Sermorelin
Biologically active fragment of natural GHRH. It physiologically stimulates the pituitary gland to produce GH, with a very favorable safety profile.
Also known as: GRF 1-29 NH2 · GHRH(1-29)
Specifications
| Research area | Growth Hormone Axis | ||
|---|---|---|---|
| Half-life | ~12 min | ||
| Molecular weight | 3357.9 Da | ||
| Amino acid residues | 29 | ||
| CAS number | 86168-78-7 | ||
| Formula | C₁₄₉H₂₄₆N₄₄O₄₂S | ||
Research areas
- Mechanism of action
- Synthetic 29-amino acid analogue of endogenous GHRH(1-44) that binds the pituitary GHRH receptor to stimulate pulsatile GH release. Preserves natural pituitary feedback through intact somatostatin regulation, making it a physiologically representative model for GH axis research.
- Reported research ranges
- 200–500 mcg subcutaneously before bedtime.
- Reported adverse effects
- Redness at the injection site, facial flushing, tingling. Generally very well tolerated.
- Storage and handling
- Refrigerate at 2–8 °C after reconstitution. The powder is stable at room temperature for up to 18 months.
Research focus
- Pulsatile GH release and GHRH receptor binding kinetics
- Lean tissue signaling and nitrogen retention models
- Pituitary somatotroph cell stimulation
- Somatostatin feedback regulation of the GH axis
- Age-related GH decline and secretagogue response
Overview
Sermorelin is a synthetic analog of growth hormone-releasing hormone (GHRH), utilized in preclinical models to investigate the regulatory mechanisms of growth hormone (GH). This peptide is particularly intriguing for researchers due to its ability to induce controlled pulses of GH, allowing for a more detailed study of signaling in lean tissue and the feedback mechanisms of the pituitary gland.
Scientists are studying Sermorelin to gain a better understanding of the effects of GH on metabolism and cellular growth. With a purity of 99% or higher it is regarded as a reliable resource for research. Its application in preclinical models is aiding in unraveling the complexities of hormonal regulation and its implications in various physiological conditions.
This material is published for scientific and educational reference. It is not medical advice, not a treatment recommendation, and not an offer to sell. Compounds discussed are for research and laboratory use only.
← All compounds