Recovery & Tissue Repair
TB-500
Synthetic peptide derived from thymosin beta-4, a natural protein found in nearly all cells. A potent agent for muscle recovery and tissue repair.
Also known as: Thymosin Beta-4 · Tβ4
Specifications
| Research area | Recovery & Tissue Repair | ||
|---|---|---|---|
| Half-life | 60–90 min | ||
| Molecular weight | 4963 Da | ||
| Amino acid residues | 43 | ||
| CAS number | 77591-33-4 | ||
| Formula | C₂₁₂H₃₅₀N₅₆O₇₈S | ||
| Sequence | Ac-Ser-Asp-Lys-Pro (active 4-aa fragment of Thymosin β-4) | ||
| Designation | Thymosin Beta-4 Fragment 17-23 | ||
Pharmacokinetics
| Half-life | 60–90 min | ||
|---|---|---|---|
| T-max | ~1 h | ||
| Route | Subcutaneous / intramuscular (research use) | ||
Receptor targets
| G-actin (cytoskeletal target) | Sequestration / cell migration | ||
|---|---|---|---|
| eNOS pathway | Angiogenic signaling | ||
| NF-κB axis | Anti-inflammatory modulation | ||
Signalling cascade
- G-actin sequestration
- Cytoskeletal remodeling
- Cell migration
- Tissue repair
Research areas
- Mechanism of action
- Synthetic fragment of Thymosin Beta-4 that sequesters G-actin to promote cytoskeletal remodeling and cell migration. Upregulates anti-inflammatory gene expression via NF-κB inhibition and stimulates angiogenesis through eNOS and VEGF pathways.
- Reported research ranges
- 2–2.5 mg twice a week for 4–6 weeks (loading phase), then 2 mg once a week.
- Reported adverse effects
- Transient fatigue, mild headache. Rarely: dizziness or post-injection nausea.
- Storage and handling
- Refrigerate at 2–8 °C after reconstitution. Lyophilized powder is stable at room temperature for up to 24 months.
Research focus
- Tissue repair and wound healing acceleration
- Cell migration and cytoskeletal dynamics (actin sequestration)
- Inflammatory resolution via NF-κB pathway inhibition
- Angiogenesis and microvascular remodeling
- Cardiac and skeletal muscle recovery in preclinical models
Overview
TB-500 is a synthetic peptide fragment composed of 43 amino acids that has been the subject of research in preclinical models. Its primary interest lies in its ability to facilitate tissue repair, promote cell migration, and assist in the resolution of inflammation. These aspects are fundamental in the study of cellular regeneration and the research into injuries.
Researchers have explored how TB-500 may influence these biological processes, making it a promising focus of study in the fields of molecular biology and regenerative medicine. With a purity verified by HPLC of ≥99%, its quality ensures reliable results in scientific studies.
Synedica formulation
Synedica publishes a formulation record and batch certificates for this compound.
This material is published for scientific and educational reference. It is not medical advice, not a treatment recommendation, and not an offer to sell. Compounds discussed are for research and laboratory use only.
← All compounds