Endocrine & Reproductive
PT-141
Cyclic melanocortin agonist with MC3R and MC4R selectivity. Studied for central dopaminergic and serotonergic signalling in neuroendocrine models.
Also known asBremelanotide
Identity
Residue chain
One bead per amino acid residue, N-terminus to C-terminus. Long chains are shown truncated.
- Molecular weight
- 1025.2 Da
- Amino acid residues
- 7
- Half-life
- 2–3 h
- CAS number
- 189691-06-3
Monograph
Specifications
- Research area
- Endocrine & Reproductive
- Half-life
- 2–3 h
- Molecular weight
- 1025.2 Da
- Amino acid residues
- 7
- CAS number
- 189691-06-3
- Formula
- C₅₀H₆₈N₁₄O₁₀
- Sequence
- Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH
- Designation
- Bremelanotide (PT-141)
Pharmacokinetics
- Half-life
- 2–3 h
- T-max
- ~1 h (SC)
- Bioavailability
- ~100% (SC)
- Route
- Subcutaneous / intranasal (research use)
Receptor targets
- MC4RPrimary melanocortin agonist
- MC3RSecondary agonist
- Hypothalamic dopaminergic neuronsCentral pathway
Signalling cascade
- 1MC4R / MC3R binding
- 2Gαs / cAMP ↑
- 3Hypothalamic dopamine release
- 4Central neuroendocrine response
- Mechanism of action
- Cyclic heptapeptide melanocortin receptor agonist with selective activity at MC3R and MC4R. Acts centrally on hypothalamic dopaminergic and serotonergic circuits, modulating neuroendocrine signaling pathways distinct from peripheral vascular mechanisms.
- Storage and handling
- Refrigerate at 2–8 °C after reconstitution. Protect from light.
Research focus
- 01MC3R and MC4R receptor pharmacology and selectivity
- 02Hypothalamic neuromodulation via dopaminergic pathways
- 03Serotonergic circuit interaction and CNS signaling
- 04Melanocortin system regulation in preclinical models
- 05Vascular signaling downstream of central melanocortin activation
Overview
PT-141 (bremelanotide) is a cyclic heptapeptide melanocortin agonist with selectivity for MC3R and MC4R. It acts centrally on hypothalamic dopaminergic and serotonergic circuits, and is used as a reference compound in neuroendocrine and behavioural models.