Metabolic & Body Composition
Tesamorelin
GHRH analogue stabilised with trans-3-hexenoic acid. Studied for GHRH receptor binding, IGF-1 output and visceral adipose models.
Also known asEgrifta · TH9507
Identity
Residue chain
One bead per amino acid residue, N-terminus to C-terminus. Long chains are shown truncated.
- Molecular weight
- 5136.0 Da
- Amino acid residues
- 44
- Half-life
- ~30 min
- CAS number
- 218949-48-9
Monograph
Specifications
- Research area
- Metabolic & Body Composition
- Half-life
- ~30 min
- Molecular weight
- 5136.0 Da
- Amino acid residues
- 44
- CAS number
- 218949-48-9
- Formula
- C₂₂₁H₃₆₆N₇₂O₆₇S
- Sequence
- trans-3-hexenoyl-GHRH(1-44)NH₂ (Tyr-Ala-Asp-Ala-Ile-Phe...44 aa)
- Designation
- trans-3-hexenoyl-Tyr¹-hGRF(1-44)NH₂
Pharmacokinetics
- Half-life
- ~30 min
- T-max
- ~15 min
- C-max
- 2.9–3.5 ng/mL
- Bioavailability
- ~4% SC (peptide)
- Route
- Subcutaneous (research use)
Receptor targets
- GHRH receptorPituitary agonist
- Anterior pituitary somatotrophsEndogenous GH release
Signalling cascade
- 1GHRH-R binding
- 2Gαs activation
- 3cAMP ↑
- 4GH secretion
- 5Hepatic IGF-1 production
- 6Lipolysis (visceral fat)
- Mechanism of action
- Synthetic analogue of endogenous GHRH(1-44) stabilized with trans-3-hexenoic acid at the N-terminus. Binds pituitary GHRH receptors to stimulate endogenous GH secretion and downstream IGF-1 production while preserving natural feedback regulation via somatostatin.
- Storage and handling
- Refrigerate at 2–8 °C after reconstitution. Do not freeze.
Research focus
- 01Visceral adipose tissue metabolism and lipolysis
- 02IGF-1 axis activation and growth factor cascade
- 03Endocrine feedback regulation via somatostatin
- 04Lipodystrophy and metabolic dysfunction models
- 05Sustained GHRH receptor binding pharmacokinetics
Overview
Tesamorelin is a GHRH analogue stabilised with trans-3-hexenoic acid at the N-terminus, which slows DPP-IV cleavage. It binds pituitary GHRH receptors to raise endogenous GH and downstream IGF-1, and is used in visceral adipose and endocrine feedback models.