Metabolic research area

Retatrutide, tirzepatide and semaglutide

Metabolic molecules in the Synedica range
Molecule	Retatrutide	Tirzepatide	Semaglutide
Receptors activated	3	2	1
Receptor targets	GIP receptor GLP-1 receptor Glucagon receptor	GIP receptor GLP-1 receptor	GLP-1 receptor
Mechanism	A single peptide agonist of the GIP, GLP-1 and glucagon receptors.	A single peptide agonist of the two incretin receptors, GIP and GLP-1.	A GLP-1 receptor agonist. A fatty acid side chain lets it bind albumin in the blood, which slows its clearance.
Formats and strengths	Reta Pen 40mg40mg · Injection pen Reta Liquid 120mg120mg / 6ml · Liquid, subcutaneous Reta Pen 60mg60mg · Injection pen	Tirze Pen 40mg40mg · Injection pen	Sema Pen 8mg8mg · Injection pen
Concentration	Reta Pen 40mgNot published Reta Liquid 120mg20mg/ml Reta Pen 60mg20mg/ml	Tirze Pen 40mgNot published	Sema Pen 8mgNot published
Published certificates	Reta Pen 40mg4 published Reta Liquid 120mg3 published Reta Pen 60mg4 published	Tirze Pen 40mgNot published	Sema Pen 8mgNot published
Instruction booklet	Reta Pen 60mg	Not published	Not published
Molecular weight	4769.5 Da	4813.5 Da	4113.6 Da
Reported half-life	~6 days	~5 days	~7 days
Library entry	Open library entry	Open library entry	Open library entry

Retatrutide

Receptors activated: 3
Receptor targets: GIP receptor
GLP-1 receptor
Glucagon receptor
Mechanism: A single peptide agonist of the GIP, GLP-1 and glucagon receptors.
Formats and strengths: Reta Pen 40mg40mg · Injection pen
Reta Liquid 120mg120mg / 6ml · Liquid, subcutaneous
Reta Pen 60mg60mg · Injection pen
Concentration: Reta Pen 40mgNot published
Reta Liquid 120mg20mg/ml
Reta Pen 60mg20mg/ml
Published certificates: Reta Pen 40mg4 published
Reta Liquid 120mg3 published
Reta Pen 60mg4 published
Instruction booklet: Reta Pen 60mg
Molecular weight: 4769.5 Da
Reported half-life: ~6 days
Library entry: Open library entry

Tirzepatide

Receptors activated: 2
Receptor targets: GIP receptor
GLP-1 receptor
Mechanism: A single peptide agonist of the two incretin receptors, GIP and GLP-1.
Formats and strengths: Tirze Pen 40mg40mg · Injection pen
Concentration: Tirze Pen 40mgNot published
Published certificates: Tirze Pen 40mgNot published
Instruction booklet: Not published
Molecular weight: 4813.5 Da
Reported half-life: ~5 days
Library entry: Open library entry

Semaglutide

Receptors activated: 1
Receptor targets: GLP-1 receptor
Mechanism: A GLP-1 receptor agonist. A fatty acid side chain lets it bind albumin in the blood, which slows its clearance.
Formats and strengths: Sema Pen 8mg8mg · Injection pen
Concentration: Sema Pen 8mgNot published
Published certificates: Sema Pen 8mgNot published
Instruction booklet: Not published
Molecular weight: 4113.6 Da
Reported half-life: ~7 days
Library entry: Open library entry

Where the figures come from

Formats, strengths, concentrations and certificates come from the product records and the published certificates. Molecular weight and half-life are reference values for the molecule from the Synedica library. They were not measured on Synedica batches.

The table covers receptors, presentation and documentation only.

Research Use Only

Material referenced on this site is supplied for laboratory and analytical research use only. It is not a drug, biologic, medical device, dietary supplement, or cosmetic, is not intended for human or veterinary use, and has not been evaluated by the U.S. Food and Drug Administration. Nothing on this site is medical advice or a recommendation to diagnose, treat, cure, or prevent any condition. Visitors are solely responsible for determining and complying with the laws applicable to research material in their jurisdiction.